For research use only. We do not sell to patients.
Rhein
CAS No. : 478-43-3
Biological Activity：Rhein is a lipophilic anthraquinone extensively found in medicinal herbs, and has many pharmacological effects, including epatoprotective, nephroprotective, anti-inflammatory, antioxidant, anticancer, and antimicrobial activities.
IC50 value:
Target:
In vitro: Rhein (0.1 and 1 mg/mL) evidently suppressed cell proliferation and mitogen-activated protein (MAP) kinase activation in human colon adenocarcinoma cells (Caco-2) but significantly lessened H2O2-induced DNA damage and the elevated MDA and ROS levels induced by H2O2/Fe2+ at the concentrations of 0.1–10 mg/mL [1].
In vivo: Oral administration of rhein (150 mg/kg/d) evidently ameliorated renal interstitial fibrotic lesions and attenuated the expression of α-SMA and deposition of fibronectin (FN) in mice with renal interstitial fibrosis induced by unilateral ureteral obstruction. Rhein also suppressed TGF-β1 and its type I receptor expression in obstructed kidneys [1]. The biochemical parameters results of IgAN model rats showed that rhein-prevented and rhein-treated both improved the biochemical parameters and relieved renal pathological injury. The expressions of renal tissue TLR4, TGF-β1, but not TLR9 were significantly elevated in IgAN model rats (P < 0.05). Rhein-prevented and rhein-treated both inhibited TLR4 and TGF-β1 expressions [2].
Research Area：Cancer|Infection|Inflammation/Immunology
Targets：Autophagy|Reactive Oxygen Species|Bacterial
Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;
Related Small Molecules:D-α-Hydroxyglutaric acid disodium;Sandramycin;Chitoheptaose heptahydrochloride;LLO (91-99);Gepotidacin;Oritavancin;Azlocillin sodium salt;Herbimycin A;Antibacterial agent 45;Leucomycin;Isouvaretin;N-Acetyl-D-cysteine;Antibacterial agent 99;Nafcillin;Antitubercular agent-28;Ochromycinone;Staurosporine;Topoisomerase I/II inhibitor 3;Nucleocidin;CYPMPO;(±)-Leucine-13C-1;Ciclopirox-d11;Antioxidant agent-5
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
About Us:
- MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use；
- Structurally and synthetically diverse biologically active compounds；
- roduct quality is the key to our success and we take pride in offering only the highest-grade products.；
- We provide HNMR, LC-MS, HPLC, stability testing and activity assays of our products to clients.；
- Product identity, quality, purity and activity are assured by our robust quality control programs and procedures.；
- Customized order volume ranging from milligrams to kilograms scale；
Structurally and synthetically diverse biologically active compounds；
We provide customer-oriented services. To explore more, please contact us at [email protected]. Our team will gladly assist you.
