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SCH-23390 maleate

CAS No. : 87134-87-0

Biological Activity：SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective dopamine D₁-like receptor antagonist with K_is of 0.2 nM and 0.3 nM for the D₁ and D₅ receptor, respectively. SCH-23390 maleate is a potent and high efficacy human 5-HT_2C receptor agonist with a K_i of 9.3 nM. SCH-23390 maleate also binds with high affinity to the 5-HT₂ and 5-HT_1C receptors. SCH-23390 maleate inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC₅₀ of 268 nM^[2]^[3].

Research Area：Neurological Disease

Targets：Dopamine Receptor|5-HT Receptor|Potassium Channel

Related Small Molecules:F 13714;Alizapride hydrochloride;Thioproperazine;Mosapride-d5;Bromopride-d3;Kv3 modulator 2;Nuciferine;Glaucine;Renzapride;SB-277011 dihydrochloride;Brompheniramine-d6 maleate;Pinacidil;LY 344864 racemate;Harmine hydrochloride;AMP-PNP tetralithium;MIF-1 TFA;Valerenic acid;IK1 inhibitor PA-6;Arotinolol;Sulpiride

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