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Harmane
CAS No. : 486-84-0
Biological Activity：Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively). Harmane exhibits comutagenic effect[2][3][4].
Research Area：Cancer|Neurological Disease
Targets：Adrenergic Receptor|Monoamine Oxidase|Imidazoline Receptor
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