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LC-2

CAS No. : 2502156-03-6

Biological Activity：LC-2 is a potent and first-in-class von Hippel-Lindau-based PROTAC capable of degrading endogenous KRAS G12C, with DC₅₀s between 0.25 and 0.76 μM. LC-2 covalently binds KRAS G12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRAS G12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRAS G12C cell lines^[2].

Research Area：Cancer

Targets：PROTACs|Ras

Related Screening Libraries:Bioactive Compound Library Plus;

Related Small Molecules:PROTAC Sirt2 Degrader-1;DB0614;PROTAC VEGFR-2 degrader-2;dTAGV-1-NEG;Deltarasin hydrochloride;CCT367766 formic;ZINC09659342;KRAS G12C inhibitor 56;CCG-232601;KRAS G12D inhibitor 14;HDAC6 degrader-1;1A-116;PROTAC Axl Degrader 2;PhosTAC7;MS98;KRAS G12D inhibitor 10;KRAS G12C inhibitor 20;JPS014;PROTAC PARP1 degrader;KRAS G12C inhibitor 24;MD-224;RM-018;KRAS G12C inhibitor 14;FKBP12 PROTAC dTAG-7;SJ10542;APS6-45;MS8815;6H05;RIP2 Kinase Inhibitor 4;KRpep-2d TFA

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