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TM6089
CAS No. : 863421-32-3
Biological Activity：TM6089 is a unique Prolyl Hydroxylase (PHD) inhibitor which stimulates HIF activity without iron chelation and induces angiogenesis and exerts organ protection against ischemia. Local administration of TM6089 enhances angiogenesis, and oral administration stimulates HIF activity in transgenic rats expressing a hypoxia-responsive reporter vector.
Research Area：Cardiovascular Disease
Targets：HIF/HIF Prolyl-Hydroxylase
Related Screening Libraries:Bioactive Compound Library Plus;Epigenetics Compound Library;Immunology/Inflammation Compound Library;Metabolism/Protease Compound Library;Reprogramming Compound Library;Oxygen Sensing Compound Library;Anti-Cardiovascular Disease Compound Library;Glutamine Metabolism Compound Library;Anti-Cancer Metabolism Compound Library;Angiogenesis-Related Compound Library;Transcription Factor-Targeted Library;
Related Small Molecules:TC-S 7009;Glucosamine-13C hydrochloride;HIF1-IN-3;Prolyl Hydroxylase inhibitor 1;Glucosamine-13C6,15N hydrochloride;HIF-PHD-IN-1;AKBA;LW6;HIF-2α-IN-5;HIF-1/2α-IN-2;GEM-5;HIF-1/2α-IN-1;Roxadustat;Daprodustat;Acetylarenobufagin;Zifcasiran;Acriflavine hydrochloride;BAY 87-2243;PHD-1-IN-1;PT-2385;ZINC13466751;(Rac)-Dencichine;Enarodustat;HIF-2α-IN-6;ENMD-1198
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