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(+)-Kavain
CAS No. : 500-64-1
Biological Activity：(+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. (+)-Kavain is shown to bind at the α4β2δ GABAA receptor and potentiate GABA efficacy[2]. (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied[4].
Research Area：Metabolic Disease|Neurological Disease
Targets：Calcium Channel|Sodium Channel|GABA Receptor
Related Screening Libraries:Natural Product Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Membrane Transporter/Ion Channel Compound Library;Neuronal Signaling Compound Library;Natural Product Library;FDA-Approved Drug Library;CNS-Penetrant Compound Library;Drug Repurposing Compound Library;Medicine Food Homology Compound Library;Neurotransmitter Receptor Compound Library;Traditional Chinese Medicine Active Compound Library;FDA Approved & Pharmacopeial Drug Library;Anti-Alzheimer’s Disease Compound Library;Anti-Parkinson’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;Food-Sourced Compound Library ;Plant-Sourced Natural Product Library;Human Metabolite Library;
Related Small Molecules:SKF89976A hydrochloride;Benidipine hydrochloride;Lu AE98134;CaV1.3 antagonist-1;14-Deoxyandrographolide;Zandatrigine;mGAT-IN-1;(Rac)-MEM 1003;Glaucine;Veratridine;Efonidipine hydrochloride monoethanolate;L-Ascorbic acid sodium salt;Brompheniramine-d6 maleate;MRS 1523;GX-674;Nilvadipine;Alpidem;Dibucaine;FG8119;Valerenic acid;Lercanidipine;CP-060;Sodium Channel inhibitor 2;3-Deoxyaconitine
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