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AACOCF3

CAS No. : 149301-79-1

Biological Activity：AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeant trifluoromethyl ketone analog of arachidonic acid. AACOCF3 is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). AACOCF3 blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. AACOCF3 has the potential for the research of cardiovascular disease^[2]^[3].

Research Area：Cardiovascular Disease

Targets：Phospholipase

Related Small Molecules:GK563;DPTIP;Cambinol;Neomycin sulfate;ONO-RS-082;ARN19874;LEI-401;ST271;Melittin TFA;(S)-Bromoenol lactone;GK187;D-Erythro-dihydrosphingosine-d7;FKGK11;PACOCF3;DL-erythro-Dihydrosphingosine;1-Naphthaleneacetic acid potassium salt;C12 NBD Sphingomyelin;ML-298;sPLA2-X Inhibitor 31;Tanshinone I;(R)-Bromoenol lactone;Ecopladib;LY 178002;CAY10502;(2E)-OBAA;ML348

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