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Phenoxodiol
CAS No. : 81267-65-4
Biological Activity：Phenoxodiol (Idronoxil), a synthetic analog of Genestein, activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol also inhibits DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner[2].
Research Area：Cancer
Targets：Topoisomerase|Caspase|Apoptosis
Related Screening Libraries:Natural Product-like Compound Library;Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Cell Cycle/DNA Damage Compound Library;Anti-Cancer Compound Library;Clinical Compound Library;Anti-Aging Compound Library;Drug Repurposing Compound Library;Anti-Lung Cancer Compound Library;Rare Diseases Drug Library;Human Metabolite Library;Anti-Prostate Cancer Compound Library;
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