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Polmacoxib

CAS No. : 301692-76-2

Biological Activity：Polmacoxib (CG100649) is a first-in-class, orally active nonsteroidal anti-inflammatory drug (NSAID) which is a dual inhibitor of COX-2 (IC₅₀ around 0.1 μg/ml) and carbonic anhydrase. Polmacoxib inhibits colorectal adenoma and tumor growth in mouse models^[2].

Research Area：Cancer

Targets：Carbonic Anhydrase|COX

Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Metabolism/Protease Compound Library;FDA-Approved Drug Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Drug Repurposing Compound Library;Pyroptosis Compound Library;Orally Active Compound Library;FDA Approved & Pharmacopeial Drug Library;Anti-Pancreatic Cancer Compound Library;Anti-Colorectal Cancer Compound Library ;Antidepressant Compound Library;FDA-Approved Anticancer Drug Library;Anti-Prostate Cancer Compound Library;Non-steroidal Anti-Inflammatory Compound Library;

Related Small Molecules:Akt/NF-κB/JNK-IN-1;Enpp/Carbonic anhydrase-IN-1;COX-2/5-LOX-IN-3;hCAIX-IN-8;Ampyrone;COX-2-IN-24;Zaltoprofen-d7;Phenylsulfamide;α-Vitamin E-d6;1-Hydroxy-ibuprofen;Asaraldehyde;Benzolamide;(-)-Epicatechin;20(S)-Ginsenoside Rg3;Ginsenoside Rd;Nimesulide D5;COX-2/5-LOX-IN-1;(E)-Dehydrodiconiferyl alcohol;hCAIX/XII-IN-1;S-(+)-Marmesin;Tazofelone;CAXII-IN-1;Catechin-13C3;hCAIX/XII-IN-2;Diclofenac-d4;hCAIX-IN-12;Proglumetacin;Ethoxycoronarin D

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