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GSK2194069
CAS No. : 1332331-08-4
Biological Activity：GSK2194069 is a potent inhibitor of β-ketoyl reductase (KR) of fatty acid synthase (FASN), with an IC50 value of 7.7 nM. GSK2194069 shows specifically inhibitory effect on FAS expressing cancer cells, by acting potent efficacy on acetoacetyl-CoA, NADPH with IC50 or Ki values of 4.8 nM and 5.6 nM, respectively[2][3].
Research Area：Cancer
Targets：Fatty Acid Synthase (FASN)
Related Screening Libraries:Bioactive Compound Library Plus;Metabolism/Protease Compound Library;Anti-Cancer Compound Library;Chemical Probe Library;Anti-Cancer Metabolism Compound Library;Anti-Obesity Compound Library;Lipid Metabolism Compound Library ;Targeted Diversity Library;Protein-protein Interaction Inhibitor Library;
Related Small Molecules:UCM05;Pedunculoside;Lycorine;Orlistat;HS80;Cerulenin;Praeruptorin B;Albaspidin AP;FT113;Pseudoprotodioscin;TVB-3664;Leelamine-d4 hydrochloride;Leelamine hydrochloride;FASN-IN-4;BI 99179;Fatostatin hydrobromide;Anti-Mouse Fas Ligand Antibody;FASN-IN-1;Dihydrocurcumin;Agrimol B;PF429242 dihydrochloride;FGH10019;FASN-IN-3;trans-C75;Betulin;trans-Chalcone;TVB-3166
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