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APS-2-79

CAS No. : 2002381-25-9

Biological Activity：APS-2-79 is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATP^biotin binding to KSR2 within the KSR2-MEK1 complexe with an IC₅₀ of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling.

Research Area：Cancer

Targets：MEK

Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;MAPK Compound Library;Anti-Cancer Compound Library;Oxygen Sensing Compound Library;Ferroptosis Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Obesity Compound Library;Angiogenesis-Related Compound Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;

Related Small Molecules:Avutometinib;Cobimetinib racemate;EBI-1051;CHMFL-EGFR-202;BI-847325;MAP855;RGB-286638;Binimetinib;PD0325901-O-C2-dioxolane;Gossypetin;PD184161;Isorhamnetin;MEK4 inhibitor-1;CI-1040;GDC-0623;TAK-733;trans-Zeatin;Selumetinib-d4;Hypothemycin;MEK1/2-IN-2;PD 198306;Zapnometinib;trans-Zeatin-d5

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