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EW-7195
CAS No. : 1352609-28-9
Biological Activity：EW-7195 is a potent and selective ALK5 (TGFβR1) inhibitor with an IC50 of 4.83 nM. EW-7195 has >300-fold selectivity for ALK5 over p38α. EW-7195 efficiently inhibits TGF-β1-induced Smad signaling, epithelial-to-mesenchymal transition (EMT) and breast tumour metastasis to the lung.
Research Area：Cancer
Targets：p38 MAPK|TGF-β Receptor
Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;MAPK Compound Library;TGF-beta/Smad Compound Library;Anti-Cancer Compound Library;Reprogramming Compound Library;Oxygen Sensing Compound Library;Pyroptosis Compound Library;Anti-Breast Cancer Compound Library;Anti-Lung Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Neurodegenerative Disease-related Compound Library;Anti-Obesity Compound Library;Angiogenesis-Related Compound Library;Anti-Colorectal Cancer Compound Library ;Antidepressant Compound Library;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;Osteogenesis Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:ML347;SB-747651A dihydrochloride;Dehydrocorydaline;SKF-86002 dihydrochloride;LDN193189 (GMP);TGFβRI-IN-4;ALK5-IN-6;TGFβ-IN-1;Pexmetinib;SB 242235;p-nitro-Pifithrin-α;TA-01;Anti-inflammatory agent 7;MW-150;VX-702;R1487 Hydrochloride;Chromenone 1;MBP MAPK Substrate;Isoliquiritin apioside;Sesamolin;OD36;ALK5-IN-32;MAPK13-IN-1;SB-505124 hydrochloride;PF-05381941;K02288;Semapimod tetrahydrochloride;ALK5-IN-28
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