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PD-166793
CAS No. : 199850-67-4
Biological Activity：PD-166793 is a potent, selective, orally active and wide‐broad spectrum inhibitor of MMP, exhibiting nanomolar potency against MMP-2, MMP-3 and MMP-13 (IC50=4, 7, and 8 nM, respectively) and micromolar potency vs MMP-1, -7 and -9 (IC50=6.0, 7.2, and 7.9 μM, respectively). PD-166793 can attenuate left ventricular remodeling and dysfunction in a rat model of progressive heart failure[2][3].
Research Area：Cardiovascular Disease
Targets：MMP
Related Screening Libraries:Bioactive Compound Library Plus;Metabolism/Protease Compound Library;Differentiation Inducing Compound Library;Anti-Cardiovascular Disease Compound Library;Orally Active Compound Library;Anti-Pancreatic Cancer Compound Library;Angiogenesis-Related Compound Library;Anti-Pulmonary Fibrosis Compound Library;
Related Small Molecules:WAY-170523;CTTHWGFTLC, CYCLIC;Edaravone;D-Isofloridoside;Chondroitin sulfate;Ginsenoside F4;ND-336;Epitheaflagallin 3-O-gallate;Histatin 5 TFA;GW280264X;GI254023X;XL-784 free base;PI3K/AKT-IN-2;Diethyl-pythiDC;FN-439;ONO-4817;Isoliquiritin apioside;Anticancer agent 65;Licoricidin;Astragaloside IV;Phosphoramidon Disodium;Ilomastat;DB04760;Cipemastat;Marimastat;Dnp-PLGLWA-DArg-NH2 TFA;Cynaropicrin;Ro 31-9790
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