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YM-244769 hydrochloride

CAS No. : 837424-39-2

Biological Activity：YM-244769 hydrochloride is a potent, selective and orally active Na⁺/Ca²⁺ exchanger (NCX) inhibitor. YM-244769 hydrochloride preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca²⁺ entry mode), with IC₅₀s of 18 nM and 50 nM, respectively. YM-244769 hydrochloride efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 hydrochloride can also increase urine volume and urinary excretion of electrolytes in mice^[2]^[3].

Research Area：Neurological Disease|Cardiovascular Disease

Targets：Na+/Ca2+ Exchanger

Related Screening Libraries:Bioactive Compound Library Plus;Membrane Transporter/Ion Channel Compound Library;Anti-Cardiovascular Disease Compound Library; Orally Active Compound Library;

Related Small Molecules:SN 6;SM-6586;Benzamil hydrochloride;Terfenadine;KB-R7943 mesylate;SEA0400;CGP37157;Caldaret;PPADS tetrasodium;ORM-10962;Terfenadine-d10;ORM-10103

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