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IDH889

CAS No. : 1429179-07-6

Biological Activity：IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC₅₀s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1^R132H, IDH1^R132C and IDH1^wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC₅₀ of 0.014 μM.

Research Area：Cancer

Targets：Isocitrate Dehydrogenase (IDH)

Related Screening Libraries:Bioactive Compound Library Plus;Metabolism/Protease Compound Library;Anti-Cancer Compound Library;CNS-Penetrant Compound Library;Glutamine Metabolism Compound Library;Anti-Cancer Metabolism Compound Library;Mitochondria-Targeted Compound Library;Glucose Metabolism Compound Library;

Related Small Molecules:mIDH1-IN-1;Enasidenib mesylate;AGI-12026;IDH1 Inhibitor 2;DS-1001b;BAY-1436032;Mutant IDH1-IN-1;(R,S)-Ivosidenib;AGI-5198;IDH-C227;IDH1 Inhibitor 1;AGI-6780;Mutant IDH1-IN-6;Olutasidenib;IDH-305;IDH1 Inhibitor 3;IDH2R140Q-IN-1;Vorasidenib;(S,R)-GSK321;IDH1 Inhibitor 5;Mutant IDH1 inhibitor;Mutant IDH1-IN-2;Mutant IDH1-IN-4;GSK864

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