For research use only. We do not sell to patients.
IMR-1
CAS No. : 310456-65-6
Biological Activity：IMR-1 is a novel class of Notch inhibitor targeting the transcriptional activation with an IC50 of 26 μM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth.
Research Area：Cancer
Targets：Notch
Related Screening Libraries:Bioactive Compound Library Plus;Neuronal Signaling Compound Library;Stem Cell Signaling Compound Library;Wnt/Hedgehog/Notch Compound Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Differentiation Inducing Compound Library;Anti-Breast Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Angiogenesis-Related Compound Library;Transcription Factor-Targeted Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Cancer Stem Cells Compound Library;
Related Small Molecules:ZLDI-8;Crenigacestat;FLI-06;JI051;Demcizumab;Notch inhibitor 1;Tarextumab;Notch 1 TFA;Bruceine D;Psoralidin;YO-01027 (GMP);Brontictuzumab;Semagacestat;BMS-983970;SAHM1 TFA;LY-411575;CB-103;Yhhu-3792;Jagged-1 (188-204) (TFA);Tangeretin;Z-Ile-Leu-aldehyde;tCFA15
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
About Us:
- MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use；
- Structurally and synthetically diverse biologically active compounds；
- roduct quality is the key to our success and we take pride in offering only the highest-grade products.；
- We provide HNMR, LC-MS, HPLC, stability testing and activity assays of our products to clients.；
- Product identity, quality, purity and activity are assured by our robust quality control programs and procedures.；
- Customized order volume ranging from milligrams to kilograms scale；
Structurally and synthetically diverse biologically active compounds；
We provide customer-oriented services. To explore more, please contact us at [email protected]. Our team will gladly assist you.
