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U93631

CAS No. : 152273-12-6

Biological Activity：U93631 is a GABAA receptor ligand of novel chemical structure with IC50 of 100 nM,and has been shown to induce a rapid, time-dependent decay of GABA-induced whole-cell Cl-currents in recombinant GABAA receptors.
target: GABAA receptor
IC 50: GABAA receptor[1]
In vitro: In the presence of U93631 at 5 UM, the peak amplitude decreased as a function of GABA concentration, with the half-maximal inhibitory concentration being approximately 100 nM, which is close to the Kd for the high affinity GABA site(85 nM). It appears that the drug interacts with GABA-bound receptors (at least monoliganded) and accelerates receptor desensitization,
rather than acting as an open channel blocker. [1]

Research Area：Neurological Disease

Targets：GABA Receptor

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