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Poseltinib
CAS No. : 1353552-97-2
Biological Activity：Poseltinib, an orally active, selective and irreversible Bruton’s tyrosine kinase (BTK) inhibitor (IC50 =1.95 nM), with 0.3, 2.3 and 2.4-fold selectivity for BTK over BMX, TEC and TXK, respectively. Poseltinib can covalently bind to the active site (cysteine 481 residue) of BTK, and reveales potent inhibition of B cell receptor (BCR), Fc receptor (FcR), Toll-like receptor (TLR) mediated signaling.
Research Area：Metabolic Disease
Targets：BMX Kinase|Btk|Toll-like Receptor (TLR)
Related Screening Libraries:Covalent Screening Library Plus;Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Clinical Compound Library;Small Molecule Immuno-Oncology Compound Library;Drug Repurposing Compound Library;Covalent Screening Library;Antioxidant Compound Library;Differentiation Inducing Compound Library;Oxygen Sensing Compound Library;Pyroptosis Compound Library;Anti-Blood Cancer Compound Library;
Related Small Molecules:C29;TMX-201;JAK3/BTK-IN-1;RS 09;ODN 20844;Elsubrutinib;ARQ 531;TLR7/8-IN-1;TLR8 agonist 5;PF-06250112;PCI 29732;Sulfo-ara-F-NMN;TLR7/8 antagonist 1;Gardiquimod;PF-4878691;Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH;CHMFL-EGFR-202;Avitinib;Pepinh-TRIF TFA;RN486;Afimetoran;GDC-0834 Racemate;Spebrutinib besylate;Vecabrutinib;Schaftoside
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