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LSN 3213128
CAS No. : 1941211-99-9
Biological Activity:LSN 3213128 is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), with IC50 of 16 nM for AICARFT enzyme inhibiton and 19 nM in cells. Anti-tumor activity.
Research Area:Cancer
Targets:Antifolate
Related Screening Libraries:Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Chemical Probe Library;Anti-Cancer Metabolism Compound Library;Targeted Diversity Library;
Related Small Molecules:Cycloguanil D6 Nitrate;FRα-IN-1;Edatrexate;Aminopterin;TNP-351;Metoprine;LY309887;Tetroxoprim;LY 222306;Levomefolate calcium;Lometrexol hydrate;Trimetrexate trihydrochloride;Mirvetuximab;DHFR-IN-3;Folinic acid disodium;EC0489;Folinic acid calcium;DHFR-IN-2;EC0488;Levomefolate-13C5 calcium;Pelitrexol;Fanotaprim;Aditoprime;Trimetrexate glucuronate;Diaveridine
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