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Rifapentine

CAS No. : 61379-65-5

Biological Activity：Rifapentine (DL 473) is an antibiotic compound used in the treatment of tuberculosis.
Target: Antibacterial
Rifapentine inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. A review of alternative regimens for prevention of active tuberculosis in HIV-negative individuals with latent TB found that a weekly, directly observed regimen of rifapentine with isoniazid for three months was as effective as a daily, self -administered regimen of isoniazid for nine months. But the rifapentine-isoniazid regimen had higher rates of treatment completion and lower rates of hepatotoxicity . However the rates of treatment-limiting adverse events were higher in the rifapentine-isoniazid regimen [1].

Research Area：Infection

Targets：Bacterial|Antibiotic

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