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Gnetol

CAS No. : 86361-55-9

Biological Activity：Gnetol is a phenolic compound isolated from the root of Gnetum ula Brongn. Gnetol potently inhibits COX-1 (IC₅₀ of 0.78 μM) and HDAC. Gnetol is a potent tyrosinase inhibitor with an IC₅₀ of 4.5 μM for murine tyrosinase and suppresses melanin biosynthesis. Gnetol has antioxidant, antiproliferative, anticancer and hepatoprotective activity. Gnetol also possesses concentration-dependent α-Amylase, α-glucosidase, and adipogenesis activities^[2]^[3].

Research Area：Cancer|Metabolic Disease

Targets：HDAC|Tyrosinase|COX

Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Epigenetics Compound Library;Immunology/Inflammation Compound Library;Metabolism/Protease Compound Library;Natural Product Library;Histone Modification Research Compound Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Antioxidant Compound Library;Reprogramming Compound Library;Oxygen Sensing Compound Library;Phenols Library;Traditional Chinese Medicine Active Compound Library;Anti-Breast Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Obesity Compound Library;Anti-Liver Cancer Compound Library ;Anti-Cancer Natural Product Library;Anti-inflammatory Traditional Chinese Medicine Active Compound Library;Plant-Sourced Natural Product Library;Osteogenesis Compound Library;

Related Small Molecules:Akt/NF-κB/JNK-IN-1;COX-2/5-LOX-IN-3;Pivanex;Ampyrone;COX-2-IN-24;Crotonoside;Dihydromorin;MPT0B390;Zaltoprofen-d7;RSC133;HDAC1/6-IN-1;HDAC/HSP90-IN-4;JPS014;Mirificin;XMD16-5;α-Vitamin E-d6;1-Hydroxy-ibuprofen;HDAC-IN-4;Asaraldehyde;(-)-Epicatechin;Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2;20(S)-Ginsenoside Rg3;Ginsenoside Rd;D-Tyrosine-d7;Tetrapeptide-30;HDAC-IN-27;D-Tyrosine-d4;1-Alaninechlamydocin;Nimesulide D5

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