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Sitravatinib malate

CAS No. : 2244864-88-6

Biological Activity：Sitravatinib malate (MGCD516 malate) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC₅₀s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively. Sitravatinib malate shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment^[2].

Research Area：Cancer|Inflammation/Immunology

Targets：Discoidin Domain Receptor|FLT3|VEGFR|Trk Receptor|c-Kit

Related Small Molecules:(Z)-FeCP-oxindole;JNK3 inhibitor-2;VEGFR-2-IN-24;BMS-690514;AT9283;hTrkA-IN-1;PROTAC VEGFR-2 degrader-2;(E/Z)-Zotiraciclib;Henatinib;Crotonoside;PI3K/VEGFR2-IN-1;c-Kit-IN-5-1;Flumatinib mesylate;IHMT-TRK-284;FLT3-IN-13;PDGFRα/FLT3-ITD-IN-2;FLT3/CDK4-IN-1;ANA-12;Hydroxytanshinone IIA;Chiauranib;Foretinib;ZM323881 hydrochloride;HP1142;Pexidartinib;PTC299

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