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Talabostat mesylate
CAS No. : 150080-09-4
Biological Activity：Talabostat mesylate (Val-boroPro mesylate; PT100 mesylate) is an orally active and nonselective dipeptidyl peptidase IV (DPP-IV) inhibitor (IC50 < 4 nM; Ki = 0.18 nM) and the first clinical inhibitor of fibroblast activation protein (FAP) (IC50 = 560 nM), inhibits DPP8/9 (IC50 = 4/11 nM; Ki = 1.5/0.76 nM), quiescent cell proline dipeptidase (QPP) (IC50 = 310 nM), DPP2, and some other DASH family enzymes. Antineoplastic and hematopoiesis- stimulating activities[2][3].
Research Area：Cancer|Inflammation/Immunology
Targets：Dipeptidyl Peptidase
Related Screening Libraries:Covalent Screening Library Plus;Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Metabolism/Protease Compound Library;Anti-Cancer Compound Library;Clinical Compound Library;Drug Repurposing Compound Library;Covalent Screening Library;Anti-COVID-19 Compound Library;Orally Active Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Rare Diseases Drug Library;
Related Small Molecules:Cofrogliptin;Anagliptin-d6;P32/98;Talabostat;Dutogliptin;Gosogliptin;Prodipine hydrochloride;Diprotin B;16-Hydroxycleroda-3,13-dien-15,16-olide;Gemigliptin tartrate;Teneligliptin hydrobromide hydrate;Teneligliptin-d4;DBPR108;Anagliptin hydrochloride;UAMC00039 dihydrochloride;Retagliptin;Diprotin A TFA;Puromycin aminonucleoside
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