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FM-381
CAS No. : 2226521-65-7
Biological Activity：FM-381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.
Research Area：Inflammation/Immunology
Targets：JAK
Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Epigenetics Compound Library;Immunology/Inflammation Compound Library;JAK/STAT Compound Library;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Stem Cell Signaling Compound Library;Anti-Aging Compound Library;Covalent Screening Library;Differentiation Inducing Compound Library;Reprogramming Compound Library;Chemical Probe Library;Anti-Breast Cancer Compound Library;Anti-Lung Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Obesity Compound Library;Anti-Liver Cancer Compound Library ;Anti-Prostate Cancer Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:AZ-3;JAK3/BTK-IN-1;AT9283;Benzene hexabromide;(E/Z)-Zotiraciclib;JAK-IN-10;Baricitinib-d3;JAK3-IN-6;Coumermycin A1;Deucravacitinib;Momelotinib-3,3,5,5-d4;SJ10542;Delgocitinib;Upadacitinib;α7 nAchR-JAK2-STAT3 agonist 1;Filgotinib-d4;AZD-1480;JAK-IN-20;JAK3 covalent inhibitor-1;JAK3-IN-12;(R)-Reticuline-d3;JAK-IN-23;TCJL37;JAK-IN-5;NSC 42834
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