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GDC-2394
CAS No. : 2238822-07-4
Biological Activity：GDC-2394 is an orally active and selective NLRP3 inhibitor, and also inhibits IL-1β with IC50s of 0.4 μM (human IL-1β) and 0.1 μM (mouse IL-1β). GDC-2394 inhibits NLRP3-induced caspase-1 activity without inhibiting NLRC4-dependent inflammasome activation[2].
Research Area：Inflammation/Immunology
Targets：Interleukin Related|NOD-like Receptor (NLR)|Caspase
Related Small Molecules:AX-024;Ginsenoside F3;Perakizumab;Dehydrocorydaline;PNRI-299;MCC950;CTX-471;Ac-YVAD-CHO;Z-DEVD-AMC;Deucravacitinib;Dapansutrile;p-nitro-Pifithrin-α;ML132;Mulberroside A;NFAT Transcription Factor Regulator-1;IL-17A antagonist 1;Kansuinine B;Ginsenoside Rc;L67;AKN-028 acetate;5(S)15(S)-DiHETE;NOD-IN-1;IL-17A inhibitor 2;Anti-Mouse IL-1b Antibody;Raleukin;Ossirene
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