Product Name :
Nootkatone
Description:
Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, has antioxidant and anti-inflammatory effects. Nootkatone improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer’s disease.
CAS:
4674-50-4
Molecular Weight:
218.33
Formula:
C15H22O
Chemical Name:
(4R,4aS,6R)-4,4a-dimethyl-6-(prop-1-en-2-yl)-2,3,4,4a,5,6,7,8-octahydronaphthalen-2-one
Smiles :
CC(=C)[C@H]1C[C@@]2(C)[C@H](C)CC(=O)C=C2CC1
InChiKey:
WTOYNNBCKUYIKC-JMSVASOKSA-N
InChi :
InChI=1S/C15H22O/c1-10(2)12-5-6-13-8-14(16)7-11(3)15(13,4)9-12/h8,11-12H,1,5-7,9H2,2-4H3/t11-,12-,15+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{OGN/Osteoglycin Protein, Mouse (HEK293, His)} medchemexpress|{OGN/Osteoglycin Protein, Mouse (HEK293, His)} Purity & Documentation|{OGN/Osteoglycin Protein, Mouse (HEK293, His)} References|{OGN/Osteoglycin Protein, Mouse (HEK293, His)} manufacturer|{OGN/Osteoglycin Protein, Mouse (HEK293, His)} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, has antioxidant and anti-inflammatory effects. Nootkatone improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer’s disease.|Product information|CAS Number: 4674-50-4|Molecular Weight: 218.33|Formula: C15H22O|Chemical Name: (4R,4aS,6R)-4,4a-dimethyl-6-(prop-1-en-2-yl)-2,3,4,4a,5,6,7,8-octahydronaphthalen-2-one|Smiles: CC(=C)[C@H]1C[C@@]2(C)[C@H](C)CC(=O)C=C2CC1|InChiKey: WTOYNNBCKUYIKC-JMSVASOKSA-N|InChi: InChI=1S/C15H22O/c1-10(2)12-5-6-13-8-14(16)7-11(3)15(13,4)9-12/h8,11-12H,1,5-7,9H2,2-4H3/t11-,12-,15+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (458.02 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Methylcobalamin} medchemexpress|{Methylcobalamin} Endogenous Metabolite|{Methylcobalamin} Protocol|{Methylcobalamin} Description|{Methylcobalamin} custom synthesis|{Methylcobalamin} Cancer} |Shelf Life: ≥12 months if stored properly.PMID:32351141 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Nootkatone (10 mg/kg) group shows good performance in behavior experiments including Y-maze test and Morris water maze test. The results of histopathological examination and immunohistochemical analysis showed that LPS induced degeneration of neurons and activation of microglia particularly in hippocampus and Nootkatone (10 mg/kg) reversed these changes. Enzyme linked immunosorbent assay and western blot analysis also demonstrated that the model group had increased expression of IL-1β, IL-6, TNF-α, NLRP3 and NF-κB p65, especially in hippocampus relative to sham-operated group, and Nootkatone (10 mg/kg) decreased the high expression of these inflammatory cytokines.|Products are for research use only. Not for human use.|