Product Name :
CSN7b Recombinant Rabbit Monoclonal Antibody [PSH06-84]
Predicted band size :
30 kDa
Observed band size :
30 kDa
Synonyms:
COP9 Complex Homolog Subunit 7b antibody COP9 Constitutive Photomorphogenic Homolog Subunit 7b antibody COP9 Signalasome Subunit 7b antibody COP9 signalosome complex subunit 7b antibody COPS7B antibody CSN7B_HUMAN antibody JAB1 Containing Signalosome Subunit 7b antibody JAB1-containing signalosome subunit 7b antibody SGN7b antibody Signalosome subunit 7b antibody
Function :
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2.{{Etoposide} site|{Etoposide} Autophagy|{Etoposide} Technical Information|{Etoposide} In Vitro|{Etoposide} supplier|{Etoposide} Cancer} The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in protein deneddylation. Located in nucleoplasm. Part of COP9 signalosome.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within human CSN7b aa 215-264.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB
Coupling :
unconjugated
Clone number:
PSH06-84
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
PBS (pH7.{{Ajudecunoid A} medchemexpress|{Ajudecunoid A} Protocol|{Ajudecunoid A} In Vitro|{Ajudecunoid A} manufacturer|{Ajudecunoid A} Autophagy} 4), 0.PMID:22943596 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 30 kDa
Positive control :
293T cell lysate, HeLa cell lysate, Jurkat cell lysate, HL-60 cell lysate, HT-29 cell lysate, RAW264.7 cell lysate, NIH/3T3 cell lysate, C6 cell lysate, PC-12 cell lysate, Mouse testis tissue lysate, Rat testis tissue lysate.