CRTC3 Mouse Monoclonal Antibody [G8-A9]

Function :
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 ‘Ser-133’ phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells.{{Olutasidenib} web|{Olutasidenib} Isocitrate Dehydrogenase (IDH)|{Olutasidenib} Technical Information|{Olutasidenib} Purity|{Olutasidenib} manufacturer|{Olutasidenib} Autophagy} Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR) .{{Gemtuzumab} web|{Gemtuzumab} Antibody-Drug Conjugates (ADCs)|{Gemtuzumab} Biological Activity|{Gemtuzumab} In Vivo|{Gemtuzumab} supplier|{Gemtuzumab} Autophagy} Tissue specificity: Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.PMID:26446225