Product Name :
CAL-101
Description:
Idelalisib, also known as CAL-101, is a PI3K-delta inhibitor with potential immunomodulating and antineoplastic activities. CAL-101 inhibits the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), preventing the activation of the PI3K signaling pathway and thus inhibiting tumor cell proliferation, motility, and survival. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells. CAL-101 has [EC(50)] = 8nM.
CAS:
870281-82-6
Molecular Weight:
415.42
Formula:
C22H18FN7O
Chemical Name:
5-fluoro-3-phenyl-2-[(1S)-1-[(7H-purin-6-yl)amino]propyl]-3,4-dihydroquinazolin-4-one
Smiles :
CC[C@H](NC1=NC=NC2N=CNC=21)C1=NC2=CC=CC(F)=C2C(=O)N1C1C=CC=CC=1
InChiKey:
IFSDAJWBUCMOAH-HNNXBMFYSA-N
InChi :
InChI=1S/C22H18FN7O/c1-2-15(28-20-18-19(25-11-24-18)26-12-27-20)21-29-16-10-6-9-14(23)17(16)22(31)30(21)13-7-4-3-5-8-13/h3-12,15H,2H2,1H3,(H2,24,25,26,27,28)/t15-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Idelalisib, also known as CAL-101, is a PI3K-delta inhibitor with potential immunomodulating and antineoplastic activities. CAL-101 inhibits the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), preventing the activation of the PI3K signaling pathway and thus inhibiting tumor cell proliferation, motility, and survival. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic lineages.{{Amiloride hydrochloride dihydrate} web|{Amiloride hydrochloride dihydrate} Apoptosis|{Amiloride hydrochloride dihydrate} Epigenetics|{Amiloride hydrochloride dihydrate} Biological Activity|{Amiloride hydrochloride dihydrate} Formula|{Amiloride hydrochloride dihydrate} manufacturer} The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells.{{Sunvozertinib} medchemexpress|{Sunvozertinib} Btk|{Sunvozertinib} Technical Information|{Sunvozertinib} In stock|{Sunvozertinib} custom synthesis|{Sunvozertinib} Cancer} CAL-101 has [EC(50)] = 8nM.PMID:23514335 |Product information|CAS Number: 870281-82-6|Molecular Weight: 415.42|Formula: C22H18FN7O|Synonym:|CAL101|GS-1101|GS1101|GS 1101|CAL 101|Idelalisib|Chemical Name: 5-fluoro-3-phenyl-2-[(1S)-1-[(7H-purin-6-yl)amino]propyl]-3,4-dihydroquinazolin-4-one|Smiles: CC[C@H](NC1=NC=NC2N=CNC=21)C1=NC2=CC=CC(F)=C2C(=O)N1C1C=CC=CC=1|InChiKey: IFSDAJWBUCMOAH-HNNXBMFYSA-N|InChi: InChI=1S/C22H18FN7O/c1-2-15(28-20-18-19(25-11-24-18)26-12-27-20)21-29-16-10-6-9-14(23)17(16)22(31)30(21)13-7-4-3-5-8-13/h3-12,15H,2H2,1H3,(H2,24,25,26,27,28)/t15-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|