Product Name :
Rogaratinib
Description:
Rogaratinib (BAY1163877) is a potent and selective fibroblast growth factor receptor (FGFR) inhibitor.
CAS:
1443530-05-9
Molecular Weight:
466.56
Formula:
C23H26N6O3S
Chemical Name:
4-{[4-amino-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)-6-(methoxymethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl}piperazin-2-one
Smiles :
CC1C=C2C=C(SC2=C(C=1)OC)C1C(COC)=C(CN2CCNC(=O)C2)N2N=CN=C(N)C2=1
InChiKey:
HNLRRJSKGXOYNO-UHFFFAOYSA-N
InChi :
InChI=1S/C23H26N6O3S/c1-13-6-14-8-18(33-22(14)17(7-13)32-3)20-15(11-31-2)16(9-28-5-4-25-19(30)10-28)29-21(20)23(24)26-12-27-29/h6-8,12H,4-5,9-11H2,1-3H3,(H,25,30)(H2,24,26,27)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Carbendazim} medchemexpress|{Carbendazim} Anti-infection|{Carbendazim} Technical Information|{Carbendazim} Formula|{Carbendazim} manufacturer|{Carbendazim} Autophagy}
Shelf Life:
≥12 months if stored properly.{{Insulin lispro} medchemexpress|{Insulin lispro} Purity & Documentation|{Insulin lispro} In stock|{Insulin lispro} manufacturer|{Insulin lispro} Cancer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:24982871
Additional information:
Rogaratinib (BAY1163877) is a potent and selective fibroblast growth factor receptor (FGFR) inhibitor.|Product information|CAS Number: 1443530-05-9|Molecular Weight: 466.56|Formula: C23H26N6O3S|Chemical Name: 4-{[4-amino-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)-6-(methoxymethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]methyl}piperazin-2-one|Smiles: CC1C=C2C=C(SC2=C(C=1)OC)C1C(COC)=C(CN2CCNC(=O)C2)N2N=CN=C(N)C2=1|InChiKey: HNLRRJSKGXOYNO-UHFFFAOYSA-N|InChi: InChI=1S/C23H26N6O3S/c1-13-6-14-8-18(33-22(14)17(7-13)32-3)20-15(11-31-2)16(9-28-5-4-25-19(30)10-28)29-21(20)23(24)26-12-27-29/h6-8,12H,4-5,9-11H2,1-3H3,(H,25,30)(H2,24,26,27)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 5 mg/mL (10.72 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Of the 24 cell lines, 2 FGFR1-amplified lung cancer (LC) cell lines, H1581 and DMS114, show extreme sensitivity to Rogaratinib (BAY1163877) (GI50 values ranging from 36 to 244 nM). Treatment with Rogaratinib results in a significant decrease in colonies formed by H1581P cells, but not by H1581AR and BR cells. Ectopic expression of Met significantly induces resistance to Rogaratinib in MTT assays. Met overexpression induces activation of downstream extracellular signal-regulated kinase 1/2 (ERK1/2) and AKT, which cannot be abrogated by Rogaratinib treatment.|Products are for research use only. Not for human use.|