Product Name :
LY 254155
Description:
LY 254155, an antifolate, inhibits hGARFT and binds to mFBP with Kis of 2.1±0.2 and 1.7±0.1 nM, respectively.
CAS:
135503-67-2
Molecular Weight:
449.48
Formula:
C19H23N5O6S
Chemical Name:
(2S)-2-{[5-(2-{2-amino-4-oxo-3H,4H,5H,6H,7H,8H-pyrido[2,3-d]pyrimidin-6-yl}ethyl)thiophen-2-yl]formamido}pentanedioic acid
Smiles :
NC1NC(=O)C2CC(CNC=2N=1)CCC1=CC=C(S1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
InChiKey:
GQCXGHHHNACOGE-ACGXKRRESA-N
InChi :
InChI=1S/C19H23N5O6S/c20-19-23-15-11(16(27)24-19)7-9(8-21-15)1-2-10-3-5-13(31-10)17(28)22-12(18(29)30)4-6-14(25)26/h3,5,9,12H,1-2,4,6-8H2,(H,22,28)(H,25,26)(H,29,30)(H4,20,21,23,24,27)/t9?,12-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
LY 254155, an antifolate, inhibits hGARFT and binds to mFBP with Kis of 2.1±0.2 and 1.7±0.1 nM, respectively.|Product information|CAS Number: 135503-67-2|Molecular Weight: 449.48|Formula: C19H23N5O6S|Chemical Name: (2S)-2-{[5-(2-{2-amino-4-oxo-3H,4H,5H,6H,7H,8H-pyrido[2,3-d]pyrimidin-6-yl}ethyl)thiophen-2-yl]formamido}pentanedioic acid|Smiles: NC1NC(=O)C2CC(CNC=2N=1)CCC1=CC=C(S1)C(=O)N[C@@H](CCC(O)=O)C(O)=O|InChiKey: GQCXGHHHNACOGE-ACGXKRRESA-N|InChi: InChI=1S/C19H23N5O6S/c20-19-23-15-11(16(27)24-19)7-9(8-21-15)1-2-10-3-5-13(31-10)17(28)22-12(18(29)30)4-6-14(25)26/h3,5,9,12H,1-2,4,6-8H2,(H,22,28)(H,25,26)(H,29,30)(H4,20,21,23,24,27)/t9?,12-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Sennoside A} MedChemExpress|{Sennoside A} HIV|{Sennoside A} Protocol|{Sennoside A} Purity|{Sennoside A} supplier|{Sennoside A} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Grazoprevir} medchemexpress|{Grazoprevir} SARS-CoV|{Grazoprevir} TGF-beta/Smad|{Grazoprevir} Technical Information|{Grazoprevir} Formula|{Grazoprevir} supplier} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23880095 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|LY 254155 inhibits recombinant human monofunctional glycinamide ribonucleotide formyltransferase (hGARFT) and binds to membrane folate-binding protein (mFBP) .|In Vivo:|LY 254155 is active against a broad panel of murine and human xenograft solid tumors. LY 254155 (5, 10, 20, and 40 mg/kg) inhibits murine C3H carcinoma growth in C3H mice, with % inhibition of tumor growth is 49%, 71%, 90%, and 94%, respectively.|Products are for research use only. Not for human use.|