COX2 Recombinant Rabbit Monoclonal Antibody [6J8]

Function :
Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA). Cox-1 and Cox-2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS).{{Encequidar} medchemexpress|{Encequidar} P-glycoprotein|{Encequidar} Technical Information|{Encequidar} In Vitro|{Encequidar} custom synthesis|{Encequidar} Epigenetic Reader Domain} Cox-1 is constitutively expressed in most tissues and is thought to serve in general “housekeeping” functions.{{Anacetrapib} medchemexpress|{Anacetrapib} Metabolic Enzyme/Protease|{Anacetrapib} Protocol|{Anacetrapib} References|{Anacetrapib} manufacturer|{Anacetrapib} Epigenetic Reader Domain} Cox-2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs.