Product Name :
COMP Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
cartilage oligomeric matrix protein (pseudoachondroplasia epiphyseal dysplasia 1 multiple) antibody Cartilage oligomeric matrix protein antibody Cartilage oligomeric matrix protein precursor antibody COMP antibody COMP_HUMAN antibody EDM 1 antibody EDM1 antibody EPD 1 antibody 展开
Function :
May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
KLH conjugated synthetic peptide derived from human COMP 221-320/757
Species reactivity:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep
Verify application:
WB, ELISA, IHC-P, IF, ICC
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃.{{Plinabulin} medchemexpress|{Plinabulin} Cell Cycle/DNA Damage|{Plinabulin} Biological Activity|{Plinabulin} In Vitro|{Plinabulin} custom synthesis|{Plinabulin} Cancer} When reconstituted in sterile pH 7.{{Gemcitabine} web|{Gemcitabine} Autophagy|{Gemcitabine} Protocol|{Gemcitabine} In Vitro|{Gemcitabine} custom synthesis|{Gemcitabine} Autophagy} 4 0.PMID:22943596 01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
Storage buffer solution:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
83 KDa
Positive control :
Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect.