Product Name :
COL4A1 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
Arresten antibody BSVD antibody CO4A1_HUMAN antibody COL4A1 antibody COL4A1 NC1 domain antibody COL4A2 antibody COL4A3 antibody COL4A4 antibody COL4A5 antibody collagen alpha-1(IV) chain antibody 展开
Function :
This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain.{{CHAPS} MedChemExpress|{CHAPS} Protocol|{CHAPS} References|{CHAPS} manufacturer|{CHAPS} Epigenetic Reader Domain} It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins.{{Muromonab} medchemexpress|{Muromonab} Immunology/Inflammation|{Muromonab} Biological Activity|{Muromonab} In stock|{Muromonab} custom synthesis|{Muromonab} Epigenetics} In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties.PMID:23319057 Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Synthetic peptide within human COL4A1 aa 1428-1443.
Species reactivity:
Human, Mouse, Rat
Verify application:
ELISA, WB
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
1:10,000-1:20,000
Molecular weight :
160 kDa
Positive control :
Hela cell lysate, MCF-7 cell lysate, U20S cell lysate.