Product Name :
ADAMTS5 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
A disintegrin and metalloproteinase with thrombospondin motifs 11 antibody A disintegrin and metalloproteinase with thrombospondin motifs 5 antibody A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 5 antibody A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 5 (aggrecanase 2) antibody A disintegrin-like and metalloprotease with thrombospondin type 1 motif 5 antibody A Disintigrin And Metalloproteinase with ThromboSpondin motif-5 antibody ADAM metallopeptidase with thrombospondin type 1 motif 5 antibody ADAM TS 11 antibody 展开
Function :
Metalloproteinase that plays an important role in connective tissue organization, development, inflammation, arthritis, and cell migration. ADAMTS5 is an extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including aggrecan, versican, brevican and neurocan (PubMed:16133547, PubMed:18992360).{{Cholesterol} site|{Cholesterol} Vitamin D Related/Nuclear Receptor|{Cholesterol} Biological Activity|{Cholesterol} Description|{Cholesterol} custom synthesis|{Cholesterol} Cancer} Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs.{{Demeclocycline} site|{Demeclocycline} Bacterial|{Demeclocycline} Biological Activity|{Demeclocycline} In Vivo|{Demeclocycline} supplier|{Demeclocycline} Epigenetic Reader Domain} Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its versican remodeling properties. Participates in development of brown adipose tissue and browning of white adipose tissue. Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
KLH conjugated synthetic peptide derived from human Aggrecan 2 511-610/930
Species reactivity:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit
Verify application:
WB, ELISA, IHC-P
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at -20℃ for one year.PMID:28739548 Avoid repeated freeze/thaw cycles.
Storage buffer solution:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
102 KDa
Positive control :
Expressed at low level in placenta primarily but also detected in heart and brain, cervix, uterus, bladder, esophagus, rib cartilage, chondroblastoma, fibrous tissue and a joint capsule from an arthritic patient.