Master of Bioactive Molecules | Inhibitors, Screening Libraries & Proteins
Background of Cuproptosis 1.1 Copper homeostasis in tumor cells Copper is a cofactor for essential enzymes required by the human body and can maintain their homeostasis by acting across concentration gradients[1]. Normally, intracellular copper concentrations are kept at extremely low levels, and this is also true in cancer cells. The normal function of copper ions […]
Description Desmin is a muscle-specific type III intermediate filament that is critical for muscle structural integrity. It forms myofibrils, interconnects Z-disks and strengthens muscle fibers. Desmin/DES Protein, Human (His) is the recombinant human-derived Desmin/DES protein, expressed by E. coli , with N-6*His labeled tag. The total length of Desmin/DES Protein, Human (His) is 210 a.a., with molecular […]
Description IL-2 Protein, Mouse is an immunomodulatory cytokine with widely varying functions including promotion of apoptosis, proliferation and survival of lymphocytes. Background Interleukin-2 (IL-2) is a multi-faceted cytokine, known for promoting proliferation, survival, and cell death depending on the cell type and state. For example, IL-2 facilitates cell death only in activated T cells when antigen and IL-2 are abundant. The […]
Description IGF-I/IGF-1 Protein, Human (70a.a) is a mitogenic cytokine, binds to IGF type 1 receptor, and modulates growth in many tissues, such as nervous tissue, lymphoid tissue, reproductive tissue, smooth muscle, endothelium, and bone; IGF-I/IGF-1 Protein also mediates neuroprotective mechanism. Background Insulin-like growth factor (IGF) system has been shown to modulate growth in many tissues, such […]
The Nobel Prize in Physiology or Medicine 2024 Discovery of micrornas and their role in post-transcriptional gene regulation On October 7, the Karolinska Institute in Sweden announced that the 2024 Nobel Prize in Physiology or Medicine will be awarded to American scientists Victor Ambros and Gary Ruvkun for their discovery of microRNA (miRNA) and its […]
With the increasing trend of global aging, sarcopenia has become a significant public health issue. Sarcopenia, a loss of skeletal muscle mass and function associated with aging, is a progressive and widespread skeletal muscle disease. Goji berry, also known as “Gou qi zi” in China, is a traditional Chinese herb that can enhance the structure […]
Mitochondrial biogenesis Mitochondrial quality control (MQC) is a comprehensive network that monitors mitochondrial quality and serves as an endogenous protective program, which is crucial for maintaining mitochondrial homeostasis and function[1]. MQC coordinates various processes, such as biogenesis, mitochondrial fission, fusion, mitochondrial protein degradation, and mitophagy, to collectively regulate and maintain mitochondrial homeostasis[2]. Typically, after a […]
Inflammatory PCD Pathway: PANoptosis PANoptosis is an inflammatory PCD pathway activated by specific triggers and regulated by the PANoptosome complex, which integrates key features of pyroptosis, apoptosis, and/or necroptosis. This is also the source of the “P,” “A,” and “N” in the term PANoptosis, but it cannot be solely represented by any one of these […]
Autophagy Autophagy is a fundamental process that degrades various components within the cell. Autophagy can be non-selective, where cytoplasmic materials are sequestered into autophagosomes for engulfment, typically occurring during nutrient deprivation. In contrast, selective autophagy degrades specific targets, such as damaged organelles: mitophagy, lysophagy, and ER-phagy, playing a crucial role in cellular quality control (Fig. […]
1. The Science Behind [16+8]: Intermittent Fasting First, the conclusion: It is feasible! The 16+8 weight loss method involves eating all three meals within an 8-hour window, followed by 16 hours of only water consumption, with no food intake. As early as 2022, Humaira Jamshed and colleagues published a randomized clinical trial in JAMA Internal […]