Product Name :
L-168049
Description:
L-168049 is a potent, selective, orally active and non-competitive glucagon receptor antagonist with IC50s of 3.7 nM, 63 nM, and 60 nM for human, murine, and canine glucagon receptors, respectively.
CAS:
191034-25-0
Molecular Weight:
467.79
Formula:
C24H20BrClN2O
Chemical Name:
4-[3-(5-bromo-2-propoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]pyridine
Smiles :
CCCOC1=CC=C(Br)C=C1C1C=C(NC=1C1C=CN=CC=1)C1C=CC(Cl)=CC=1
InChiKey:
HHBOWXZOLYQFNY-UHFFFAOYSA-N
InChi :
InChI=1S/C24H20BrClN2O/c1-2-13-29-23-8-5-18(25)14-20(23)21-15-22(16-3-6-19(26)7-4-16)28-24(21)17-9-11-27-12-10-17/h3-12,14-15,28H,2,13H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Pemafibrate} site|{Pemafibrate} PPAR|{Pemafibrate} Biological Activity|{Pemafibrate} Formula|{Pemafibrate} manufacturer|{Pemafibrate} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
L-168049 is a potent, selective, orally active and non-competitive glucagon receptor antagonist with IC50s of 3.7 nM, 63 nM, and 60 nM for human, murine, and canine glucagon receptors, respectively.|Product information|CAS Number: 191034-25-0|Molecular Weight: 467.79|Formula: C24H20BrClN2O|Chemical Name: 4-[3-(5-bromo-2-propoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]pyridine|Smiles: CCCOC1=CC=C(Br)C=C1C1C=C(NC=1C1C=CN=CC=1)C1C=CC(Cl)=CC=1|InChiKey: HHBOWXZOLYQFNY-UHFFFAOYSA-N|InChi: InChI=1S/C24H20BrClN2O/c1-2-13-29-23-8-5-18(25)14-20(23)21-15-22(16-3-6-19(26)7-4-16)28-24(21)17-9-11-27-12-10-17/h3-12,14-15,28H,2,13H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Eptinezumab} medchemexpress|{Eptinezumab} Neuronal Signaling|{Eptinezumab} Purity & Documentation|{Eptinezumab} In Vitro|{Eptinezumab} manufacturer|{Eptinezumab} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:24423657 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|L-168049 (compound 49) inhibits glucagon (100 pM) stimulated cAMP synthesis in CHO cells expressing the human glucagon receptor (hGIAR) (IC50 of 41 nM). L-168049 blocks cAMP formation stimulated by glucagon in murine liver membranes. L-168049 increases the apparent EC50 for glucagon stimulation of adenylyl cyclase in Chinese hamster ovary cells expressing the human glucagon receptor and decreases the maximal glucagon stimulation observed, with a Kb of 25 nM.|In Vivo:|In the liver of L-G6pc−/- mice, Pck1 mRNA expression is decreased by half 6 h after the administration of L-168049 (50 mg/kg body; p.o.), demonstrating the efficiency of the suppression of glucagon signaling. In agreement with the role of glucagon in the induction of extrahepatic gluconeogenesis, the administration of the L-168049 prevents the increase of the G6pc expression in both the kidneys and intestine of 6 h-fasted L-G6pc−/- mice.|Products are for research use only. Not for human use.|