CLPX Recombinant Rabbit Monoclonal Antibody [JE62-96]

Function :
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial is an enzyme that in humans is encoded by the CLPX gene. This protein is a member of the family of AAA Proteins (AAA+ ATPase) and is to form the protein complex of Clp protease. ClpX is an ATP-dependent chaperone that can recognize protein substrates by binding to protein degradation tags. These tags can be short unstructured peptide sequences (e.g., ssrA-tag in E coli). As an essential component of ClpP protease complex, ClpX recruits degradable substrates and unfolds their tertiary structure, which requires energy provided by ATP hydrolysis.{{Zilovertamab vedotin} web|{Zilovertamab vedotin} Apoptosis|{Zilovertamab vedotin} Protocol|{Zilovertamab vedotin} In Vitro|{Zilovertamab vedotin} manufacturer|{Zilovertamab vedotin} Cancer} Subsequently, these ClpX Chaperones transfer protein substrates into the proteolytic chamber formed by ClpP tetradecamer.{{Isoniazid} site|{Isoniazid} Autophagy|{Isoniazid} Biological Activity|{Isoniazid} In Vitro|{Isoniazid} supplier|{Isoniazid} Epigenetics} In mammals, ClpXP protease is a pivotal contributor to mitochondrial protein quality control.PMID:24428212 A compromised ClpXP function usually leads to the accumulation of damaged proteins and mitochondrial dysfunctions, which believes to be potential causes for neurodegenerative diseases and aging.