Product Name :
CLK2 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
CDC like kinase 2 antibody CDC-like kinase 2 antibody CLK 2 antibody CLK kinase antibody CLK2 antibody Clk2 Scamp3 antibody CLK2_HUMAN antibody Dual specificity protein kinase CLK2 antibody hCLK 2 antibody hCLK2 antibody 展开
Function :
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution.{{Mifanertinib dimaleate} medchemexpress|{Mifanertinib dimaleate} c-Met/HGFR|{Mifanertinib dimaleate} Biological Activity|{Mifanertinib dimaleate} In stock|{Mifanertinib dimaleate} manufacturer|{Mifanertinib dimaleate} Epigenetic Reader Domain} Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
KLH conjugated synthetic peptide derived from human CLK2 401-499/499
Species reactivity:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit
Verify application:
WB, ELISA, IHC-P, IF
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃.{{ERK1/2 inhibitor 2} web|{ERK1/2 inhibitor 2} Apoptosis|{ERK1/2 inhibitor 2} Protocol|{ERK1/2 inhibitor 2} Data Sheet|{ERK1/2 inhibitor 2} manufacturer|{ERK1/2 inhibitor 2} Cancer} When reconstituted in sterile pH 7.PMID:23927631 4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
Storage buffer solution:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
60 KDa
Positive control :
Endothelial cells.