Product Name :
Tanshinone I
Description:
Tanshinone I is a diterpene with anticancer, antidiabetic, and neuroprotective properties. It inhibits proliferation in a variety of cancer cell lines, including KB/VCR, MCF-7/ADR, and K562/A02 multidrug resistance cell lines. It inhibits topoisomerase I- and topoisomerase II-mediated supercoiled DNA relaxation activity and inhibits proliferation of H358-IR and H157-IR radioresistant lung cancer cells. It reduces plasma levels of total cholesterol, triglycerides, LDL, and nonesterified fatty acids and decreases blood glucose levels in a rat model of type 2 diabetes induced by streptozotocin and a high-fat diet. Tanshinone I reduces the LPS-induced expression of TNF-α, IL-1β, and IL-6 in microglia. It is neuroprotective in a mouse model of Parkinson’s disease induced by MPTP, preventing dopaminergic cell death in the striatum and improving motor function.
CAS:
568-73-0
Molecular Weight:
276.29
Formula:
C18H12O3
Chemical Name:
1, 6-dimethyl-phenanthro[1, 2-b]furan-10, 11-dione
Smiles :
CC1=CC=CC2=C3C(=CC=C12)C1OC=C(C)C=1C(=O)C3=O
InChiKey:
AIGAZQPHXLWMOJ-UHFFFAOYSA-N
InChi :
InChI=1S/C18H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-8H,1-2H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Tanshinone I is a diterpene with anticancer, antidiabetic, and neuroprotective properties. It inhibits proliferation in a variety of cancer cell lines, including KB/VCR, MCF-7/ADR, and K562/A02 multidrug resistance cell lines. It inhibits topoisomerase I- and topoisomerase II-mediated supercoiled DNA relaxation activity and inhibits proliferation of H358-IR and H157-IR radioresistant lung cancer cells. It reduces plasma levels of total cholesterol, triglycerides, LDL, and nonesterified fatty acids and decreases blood glucose levels in a rat model of type 2 diabetes induced by streptozotocin and a high-fat diet. Tanshinone I reduces the LPS-induced expression of TNF-α, IL-1β, and IL-6 in microglia. It is neuroprotective in a mouse model of Parkinson’s disease induced by MPTP, preventing dopaminergic cell death in the striatum and improving motor function.|Product information|CAS Number: 568-73-0|Molecular Weight: 276.{{Ethambutol} MedChemExpress|{Ethambutol} Antibiotic|{Ethambutol} Technical Information|{Ethambutol} In stock|{Ethambutol} custom synthesis|{Ethambutol} Epigenetic Reader Domain} 29|Formula: C18H12O3|Synonym:|Tanshinone A|Chemical Name: 1, 6-dimethyl-phenanthro[1, 2-b]furan-10, 11-dione|Smiles: CC1=CC=CC2=C3C(=CC=C12)C1OC=C(C)C=1C(=O)C3=O|InChiKey: AIGAZQPHXLWMOJ-UHFFFAOYSA-N|InChi: InChI=1S/C18H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-8H,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: 23 mg/mL(83.24 mM). Water: Insoluble.|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Palmitic acid} MedChemExpress|{Palmitic acid} Endogenous Metabolite|{Palmitic acid} Biological Activity|{Palmitic acid} Description|{Palmitic acid} custom synthesis|{Palmitic acid} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:32261617 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Tanshinone I, an active principle isolated from Salvia miltiorrhiza (Danshen), is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells. Tanshinone I inhibits PGE2 formation from LPS-induced RAW macrophages (IC50 = 38 μM). However, this compound does not affect COX-2 activity or COX-2 expression. Tanshinone I is an inhibitor of type IIA human recombinant phospholipase A2 (PLA2) with IC50 of 11 μM. In preliminary data, tanshinone I possesses the strongest inhibitory effect on tumor necrosis factor-α (TNF-α)-induced adhesion molecules.|References:|Nizamutdinova IT, et al. Carcinogenesis, 2008, 29(10), 1885-1892.Kim SY, et al. Phytother Res, 2002, 16(7), 616-620.Products are for research use only. Not for human use.|