Product Name :
GSTO-IN-2
Description:
GSTO-IN-2 is a glutathione S-transferase inhibitor with IC50s of 3.6, 16.3, and 1.4 μM for GSTA2, GSTM1, and GSTP1-1.
CAS:
1202710-57-3
Molecular Weight:
620.77
Formula:
C33H52N2O9
Chemical Name:
(2S)-4-{[(2S)-1-{[(1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-1-[(2R)-4-carboxybutan-2-yl]-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-7-yl]oxy}-3-carboxy-1-oxopropan-2-yl]carbamoyl}-2-aminobutanoic acid
Smiles :
C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@@H](CC[C@]4(C)[C@H]3CC[C@@]21C)OC(=O)[C@H](CC(O)=O)NC(=O)CC[C@H](N)C(O)=O
InChiKey:
GEYBDXYFLCDBPT-RHGDXGROSA-N
InChi :
InChI=1S/C33H52N2O9/c1-18(4-11-28(37)38)22-7-8-23-21-6-5-19-16-20(12-14-32(19,2)24(21)13-15-33(22,23)3)44-31(43)26(17-29(39)40)35-27(36)10-9-25(34)30(41)42/h18-26H,4-17,34H2,1-3H3,(H,35,36)(H,37,38)(H,39,40)(H,41,42)/t18-,19-,20-,21+,22-,23+,24+,25+,26+,32+,33-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
GSTO-IN-2 is a glutathione S-transferase inhibitor with IC50s of 3.6, 16.3, and 1.4 μM for GSTA2, GSTM1, and GSTP1-1.|Product information|CAS Number: 1202710-57-3|Molecular Weight: 620.77|Formula: C33H52N2O9|Chemical Name: (2S)-4-{[(2S)-1-{[(1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-1-[(2R)-4-carboxybutan-2-yl]-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-7-yl]oxy}-3-carboxy-1-oxopropan-2-yl]carbamoyl}-2-aminobutanoic acid|Smiles: C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@@H](CC[C@]4(C)[C@H]3CC[C@@]21C)OC(=O)[C@H](CC(O)=O)NC(=O)CC[C@H](N)C(O)=O|InChiKey: GEYBDXYFLCDBPT-RHGDXGROSA-N|InChi: InChI=1S/C33H52N2O9/c1-18(4-11-28(37)38)22-7-8-23-21-6-5-19-16-20(12-14-32(19,2)24(21)13-15-33(22,23)3)44-31(43)26(17-29(39)40)35-27(36)10-9-25(34)30(41)42/h18-26H,4-17,34H2,1-3H3,(H,35,36)(H,37,38)(H,39,40)(H,41,42)/t18-,19-,20-,21+,22-,23+,24+,25+,26+,32+,33-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (161.{{Vibecotamab} site|{Vibecotamab} Immunology/Inflammation|{Vibecotamab} Activator|{Vibecotamab} Protocol|{Vibecotamab} In Vitro|{Vibecotamab} custom synthesis} 09 mM; Need ultrasonic).{{Atorvastatin} MedChemExpress|{Atorvastatin} HMG-CoA Reductase (HMGCR)|{Atorvastatin} Protocol|{Atorvastatin} Formula|{Atorvastatin} custom synthesis|{Atorvastatin} Epigenetic Reader Domain} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23577779 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|GSTO-IN-2 is compound 3 in the reference. GSTO-IN-2 shows synergetic effect with chemotherapy drugs against two breast cancer cell lines through the inactivation of GST isozymes. The maximal enhancement of cisplatin-induced inhibition of cell viability is observed at 50 μM GSTO-IN-2, up to 640% against MCF-7 and up to 270% against MDA-MB-231. Viability inhibition of thiotepa is enhanced by GSTO-IN-2 (25 and 50 μM), up to 170-320% against MCF-7 and up to 180-270% against MDA-MB-231..|Products are for research use only. Not for human use.|