Product Name :
CHMP2B Recombinant Rabbit Monoclonal Antibody [JE54-35]
Predicted band size :
24 kDa
Observed band size :
30 kDa
Synonyms:
ALS17 antibody Charged multivesicular body protein 2b antibody CHM2B_HUMAN antibody CHMP family, member 2B antibody CHMP2.5 antibody CHMP2b antibody Chromatin modifying protein 2b antibody Chromatin-modifying protein 2b antibody hVps2-2 antibody Vacuolar protein sorting 2, yeast, homolog of, B antibody 展开
Function :
Charged multivesicular body protein 2b is a protein that in humans is encoded by the CHMP2B gene.{{Desmosterol} web|{Desmosterol} Endogenous Metabolite|{Desmosterol} Protocol|{Desmosterol} Data Sheet|{Desmosterol} manufacturer|{Desmosterol} Epigenetic Reader Domain} It forms part of one of the endosomal sorting complexes required for transport (ESCRT) – specifically ESCRT-III – which are a series of complexes involved in cell membrane remodelling. CHMP2B forms long chains that spiral around the neck of a budding vesicle. Along with the other components of ESCRT-III, CHMP2B constricts the neck of the vesicle just before it is cleaved away from the membrane. Mutations of this gene cause chromosome 3-linked frontotemporal dementia (FTD3), which has been described in several members of one Danish family .{{MSAB} web|{MSAB} Wnt|{MSAB} Purity & Documentation|{MSAB} References|{MSAB} custom synthesis|{MSAB} Epigenetic Reader Domain} In a study of French families with several forms of frontotemporal dementia, it was found to be a relatively rare cause.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Recombinant protein within Human CHMP2B aa 103-213 / 213.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IF-Cell, IHC-P, FC
Coupling :
unconjugated
Clone number:
JE54-35
RRID:
AB_3071030
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.PMID:23892746 Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 24 kDa
Positive control :
Mouse bone marrow tissue lysate, rat bone marrow tissue lysate, human skeletal muscle tissue lysate, A549 cell lysate, A431 cell lysate, Hela cell lysate, SW620, SW1990, mouse testis tissue, mouse kidney tissue, A549.