Product Name :
CERD4 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
2810403B03Rik antibody BAF45C antibody BRG1-associated factor 45C antibody cer-d4 homolog antibody CERD4 antibody D4 zinc and double PHD fingers family member 3 antibody D4 zinc and double PHD fingers family 3 antibody DPF 3 antibody 展开
Function :
Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).{{Mefenamic acid} MedChemExpress|{Mefenamic acid} COX|{Mefenamic acid} Purity & Documentation|{Mefenamic acid} In Vivo|{Mefenamic acid} supplier|{Mefenamic acid} Epigenetic Reader Domain} Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling.{{Giemsa stain} medchemexpress|{Giemsa stain} {Fluorescent Dye}|{Giemsa stain} Protocol|{Giemsa stain} References|{Giemsa stain} manufacturer|{Giemsa stain} Cancer} It thereby probably plays an essential role in heart and skeletal muscle development.PMID:24423657
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
KLH conjugated synthetic peptide derived from human CERD4 1-100/378
Species reactivity:
Human, Mouse, Rat, Pig, Cow, Rabbit
Verify application:
WB, IHC-P, IF, ICC
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
Storage buffer solution:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
43 KDa
Positive control :