Product Name :
ADAM17 Recombinant Rabbit Monoclonal Antibody [JM10-35]
Predicted band size :
Observed band size :
Synonyms:
A disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) antibody A disintegrin and metalloproteinase domain 17 antibody ADA17_HUMAN antibody ADAM 17 antibody ADAM metallopeptidase domain 17 antibody ADAM17 antibody ADAM17 protein antibody CD 156b antibody CD156b antibody CD156b antigen antibody 展开
Function :
A disintegrin and metalloprotease 17 (ADAM17), also called TACE (tumor necrosis factor-α-converting enzyme), is an 824-amino acid polypeptide that belongs to the ADAM protein family of disintegrins and metalloproteases. ADAM17 is understood to be involved in the processing of tumor necrosis factor alpha (TNF-α) at the surface of the cell, and from within the intracellular membranes of the trans-Golgi network.{{Danuglipron} MedChemExpress|{Danuglipron} GCGR|{Danuglipron} Purity & Documentation|{Danuglipron} In stock|{Danuglipron} supplier|{Danuglipron} Autophagy} This process, which is also known as ‘shedding’, involves the cleavage and release of a soluble ectodomain from membrane-bound pro-proteins (such as pro-TNF-α), and is of known physiological importance.{{TL13-68} web|{TL13-68} Technical Information|{TL13-68} References|{TL13-68} manufacturer|{TL13-68} Autophagy} ADAM17 was the first ‘sheddase’ to be identified, and is also understood to play a role in the release of a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands, and enzymes.PMID:35227773
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within Human ADAM17 aa 757-790 / 824.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IF-Cell, IF-Tissue, FC, IP, IHC-Fr, IHC-P
Coupling :
unconjugated
Clone number:
JM10-35
RRID:
AB_3073468
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 93 kDa
Positive control :
SW480 cell lysate, HepG2 cell lysate, HepG2, SKOV-3, SW480, Hela, mouse cerebral cortex tissue, mouse brain tissue, mouse hippocampus tissue, rat brain tissue, rat hippocampus tissue.