Product Name :
ADAM15 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
A disintegrin and metalloproteinase domain 15 (metargidin) antibody A disintegrin and metalloproteinase domain 15 antibody ADA15_HUMAN antibody ADAM 15 antibody ADAM metallopeptidase domain 15 antibody Adam15 antibody and cysteine-rich protein 15 antibody Disintegrin and metalloproteinase domain-containing protein 15 antibody disintegrin-like antibody EC 3.4.24. antibody 展开
Function :
Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation.{{Aprepitant} site|{Aprepitant} Antibiotic|{Aprepitant} Protocol|{Aprepitant} Description|{Aprepitant} custom synthesis|{Aprepitant} Epigenetic Reader Domain} Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
KLH conjugated synthetic peptide derived from human ADAM15 621-720/863
Species reactivity:
Human
Verify application:
WB, ELISA, IHC-P, IF
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at -20℃ for one year.{{β-Amyloid (1-40)} site|{β-Amyloid (1-40)} Neuronal Signaling|{β-Amyloid (1-40)} Purity & Documentation|{β-Amyloid (1-40)} Formula|{β-Amyloid (1-40)} supplier|{β-Amyloid (1-40)} Autophagy} Avoid repeated freeze/thaw cycles.PMID:25955218 The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
Storage buffer solution:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
70 KDa
Positive control :
Expressed in colon and small intestine. Expressed in airway smooth muscle and glomerular mesangial cells (at protein level). Ubiquitously expressed. Overexpressed in atherosclerotic lesions. Constitutively expressed in cultured endothelium and smooth muscle. Expressed in chondrocytes. Expressed in airway smooth muscle and glomerular mesangial cells.