Product Name :
ADAM10 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
A disintegrin and metalloprotease domain 10 antibody A disintegrin and metalloproteinase domain 10 antibody AD 10 antibody AD10 antibody AD18 antibody ADA10_HUMAN antibody ADAM 10 antibody ADAM metallopeptidase domain 10 antibody ADAM10 antibody CD 156c antibody 展开
Function :
ADAM (a disintegrin and metalloprotease) proteins are a family of over 30 membrane-anchored, glycosylated, Zn2+ dependent proteases that are involved in cell-cell, cell-matrix interface related processes including fertilization, muscle fusion, secretion of TNFα (tumor necrosis factor α), and modulation of the neurogenic function of Notch and Delta. ADAM proteins possess a signal-domain, a pro-domain, a metalloprotease domain, a disintegrin domain (integrin ligand) a cysteine-rich region, an epidermal growth factor-like domain, a transmembrane domain and a cytoplasmic tail. ADAMs are expressed in brain, testis, epididymis, ovary, breast, placenta, liver, heart, lung, bone and muscle, and catalyze proteolysis, adhesion, fusion and intracellular signaling.{{M-CSF Protein, Human} MedChemExpress|{M-CSF Protein, Human} Purity & Documentation|{M-CSF Protein, Human} Description|{M-CSF Protein, Human} custom synthesis|{M-CSF Protein, Human} Cancer} ADAM10 is a TNF-processing enzyme that cleaves pro-TNF, a membrane-bound precusor protein, at Ala 76-Val 77, which causes membrane shedding of soluble TNF.{{Tamoxifen} MedChemExpress|{Tamoxifen} Estrogen Receptor/ERR|{Tamoxifen} Purity & Documentation|{Tamoxifen} Formula|{Tamoxifen} supplier|{Tamoxifen} Autophagy}
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Recombinant protein within human ADAM10 aa 60-338.PMID:23795974
Species reactivity:
Human
Verify application:
WB, IHC-P
Coupling :
unconjugated
Clone number:
RRID:
AB_3069105
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 84 kDa
Positive control :
SiHa, human prostate tissue.