Product Name :
Tomivosertib
Description:
Tomivosertib (eFT508) is a potent, highly selective, and orally active MNK1 and MNK2 inhibitor, with IC50s of 1-2 nM against both isoforms. Tomivosertib (eFT508) treatment leads to a dose-dependent reduction in eIF4E phosphorylation at serine 209 (IC50=2-16 nM) in tumor cell lines. Tomivosertib (eFT508) also dramatically downregulates PD-L1 protein abundance.
CAS:
1849590-01-7
Molecular Weight:
340.38
Formula:
C17H20N6O2
Chemical Name:
6′-[(6-aminopyrimidin-4-yl)amino]-8′-methyl-2′,5′-dihydro-1’H-spiro[cyclohexane-1,3′-imidazo[1,5-a]pyridine]-1′,5′-dione
Smiles :
CC1C=C(NC2C=C(N)N=CN=2)C(=O)N2C=1C(=O)NC12CCCCC1
InChiKey:
HKTBYUWLRDZAJK-UHFFFAOYSA-N
InChi :
InChI=1S/C17H20N6O2/c1-10-7-11(21-13-8-12(18)19-9-20-13)16(25)23-14(10)15(24)22-17(23)5-3-2-4-6-17/h7-9H,2-6H2,1H3,(H,22,24)(H3,18,19,20,21)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Trastuzumab emtansine} web|{Trastuzumab emtansine} Antibody-drug Conjugate/ADC Related|{Trastuzumab emtansine} Purity & Documentation|{Trastuzumab emtansine} Purity|{Trastuzumab emtansine} manufacturer|{Trastuzumab emtansine} Epigenetics}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Tomivosertib (eFT508) is a potent, highly selective, and orally active MNK1 and MNK2 inhibitor, with IC50s of 1-2 nM against both isoforms.{{PS10} site|{PS10} Metabolic Enzyme/Protease|{PS10} Technical Information|{PS10} In Vivo|{PS10} manufacturer|{PS10} Autophagy} Tomivosertib (eFT508) treatment leads to a dose-dependent reduction in eIF4E phosphorylation at serine 209 (IC50=2-16 nM) in tumor cell lines. Tomivosertib (eFT508) also dramatically downregulates PD-L1 protein abundance.|Product information|CAS Number: 1849590-01-7|Molecular Weight: 340.PMID:24914310 38|Formula: C17H20N6O2|Chemical Name: 6′-[(6-aminopyrimidin-4-yl)amino]-8′-methyl-2′,5′-dihydro-1’H-spiro[cyclohexane-1,3′-imidazo[1,5-a]pyridine]-1′,5′-dione|Smiles: CC1C=C(NC2C=C(N)N=CN=2)C(=O)N2C=1C(=O)NC12CCCCC1|InChiKey: HKTBYUWLRDZAJK-UHFFFAOYSA-N|InChi: InChI=1S/C17H20N6O2/c1-10-7-11(21-13-8-12(18)19-9-20-13)16(25)23-14(10)15(24)22-17(23)5-3-2-4-6-17/h7-9H,2-6H2,1H3,(H,22,24)(H3,18,19,20,21)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 4.35 mg/mL (12.78 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Tomivosertib (eFT508) reduces eIF4E phosphorylation dose-dependently at serine 209 (IC50=2-16 nM) in tumor cell lines. In a panel of appr 50 hematological cancers, Tomivosertib shows anti-proliferative activity against multiple DLBCL cell lines. Sensitivity to Tomivosertib in TMD8, OCI-Ly3 and HBL1 DLBCL cell lines is associated with dose-dependent decreases in production of pro-inflammatory cytokines including TNFα, IL-6, IL-10 and CXCL10. Further evaluation Tomivosertib mechanism of action demonstrates that decreased TNFα production correlates with a 2-fold decrease in TNFα mRNA half-life.|In Vivo:|Tomivosertib (eFT508) shows significant anti-tumor activity in the TMD8 and HBL-1 ABC-DLBCL models, both of which harbor activating MyD88 mutations. Besides, Tomivosertib combines effectively with components of R-CHOP and with novel targeted agents, including PCI-32765 and Venetoclax, in human lymphoma models.|Products are for research use only. Not for human use.|