CD86 Recombinant Rabbit Monoclonal Antibody [SJ20-00]

Product Name :
CD86 Recombinant Rabbit Monoclonal Antibody [SJ20-00]

Predicted band size :
38 kDa

Observed band size :
70 kDa

Synonyms:
Activation B7-2 antigen 3 antibody Activation B7-2 antigen antibody B-lymphocyte activation antigen B7-2 2 antibody B-lymphocyte activation antigen B7-2 antibody B7 2 antibody B7 antibody B7-2 antibody B7.2 antibody B70 antibody B72 antigen antibody 展开

Function :
Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein constitutively expressed on dendritic cells, Langerhans cells, macrophages, B-cells (including memory B-cells), and on other antigen-presenting cells. Along with CD80, CD86 provides costimulatory signals necessary for T cell activation and survival. Depending on the ligand bound, CD86 can signal for self-regulation and cell-cell association, or for attenuation of regulation and cell-cell disassociation. The CD86 gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined. Roles of both CD80 and CD86 are studied in context of many pathologies. Selective inhibition of costimulatory inhibitors was examined in a model of allergic pulmonary inflammation and airway hyper-responsiveness (AHR). Since initial host response to Staphylococcus aureus, especially the immune response based on T cells, is a contributing factor in the pathogenesis of acute pneumonia, role of the CD80/CD86 pathway in pathogenesis was investigated. The costimulatory molecules were also investigated in context of Bronchial Astma, Treg in cancer, and immunotherapy.{{Aflibercept (VEGF Trap)} site|{Aflibercept (VEGF Trap)} Protein Tyrosine Kinase/RTK|{Aflibercept (VEGF Trap)} Protocol|{Aflibercept (VEGF Trap)} Purity|{Aflibercept (VEGF Trap)} custom synthesis|{Aflibercept (VEGF Trap)} Autophagy}

Antibody Type:
Recombinant Rabbit monoclonal Antibody

Immunogen :
Synthetic peptide within Human CD86 aa 1-50 / 329.

Species reactivity:
Human, Mouse, Rat

Verify application:
WB, IP, IF-Cell

Coupling :
unconjugated

Clone number:
SJ20-00

RRID:
AB_3069745

Form :
Liquid

Concentration :
1ug/ul

Storage instructions:
Store at +4℃ after thawing.{{Biotin} medchemexpress|{Biotin} Endogenous Metabolite|{Biotin} Protocol|{Biotin} Purity|{Biotin} supplier|{Biotin} Epigenetic Reader Domain} Aliquot store at -20℃ or -80℃.PMID:27102143 Avoid repeated freeze / thaw cycles.

Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Subtype:
IgG

Purification method :
Protein A affinity purified.

ELTSA :

Molecular weight :
Predicted band size: 38 kDa

Positive control :
Daudi cell lysate, Raji cell lysate, Ramos cell lysate, Jurkat cell lysate, K-562 cell lysate, Mouse lung tissue lysate, Rat lung tissue lysate, Raji.

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