Product Name :
Silodosin-d4
Description:
Silodosin-d4 (KAD 3213-d4) is the deuterium labeled Silodosin. Silodosin (KAD 3213) is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (Ki=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with Ki values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH.
CAS:
1426173-86-5
Molecular Weight:
499.56
Formula:
C25H32F3N3O4
Chemical Name:
1-(3-hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy](1,1,2,2-²H₄)ethyl}amino)propyl]-2,3-dihydro-1H-indole-7-carboxamide
Smiles :
[2H]C([2H])(OC1=CC=CC=C1OCC(F)(F)F)C([2H])([2H])N[C@H](C)CC1=CC2CCN(CCCO)C=2C(=C1)C(N)=O
InChiKey:
PNCPYILNMDWPEY-JRBXURKDSA-N
InChi :
InChI=1S/C25H32F3N3O4/c1-17(30-8-12-34-21-5-2-3-6-22(21)35-16-25(26,27)28)13-18-14-19-7-10-31(9-4-11-32)23(19)20(15-18)24(29)33/h2-3,5-6,14-15,17,30,32H,4,7-13,16H2,1H3,(H2,29,33)/t17-/m1/s1/i8D2,12D2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Silodosin-d4 (KAD 3213-d4) is the deuterium labeled Silodosin. Silodosin (KAD 3213) is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (Ki=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with Ki values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH.{{Mevastatin} medchemexpress|{Mevastatin} Apoptosis|{Mevastatin} Biological Activity|{Mevastatin} References|{Mevastatin} supplier|{Mevastatin} Autophagy} |Product information|CAS Number: 1426173-86-5|Molecular Weight: 499.{{Bimagrumab} MedChemExpress|{Bimagrumab} TGF-beta/Smad|{Bimagrumab} Biological Activity|{Bimagrumab} References|{Bimagrumab} custom synthesis|{Bimagrumab} Epigenetic Reader Domain} 56|Formula: C25H32F3N3O4|Chemical Name: 1-(3-hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy](1,1,2,2-²H₄)ethyl}amino)propyl]-2,3-dihydro-1H-indole-7-carboxamide|Smiles: [2H]C([2H])(OC1=CC=CC=C1OCC(F)(F)F)C([2H])([2H])N[C@H](C)CC1=CC2CCN(CCCO)C=2C(=C1)C(N)=O|InChiKey: PNCPYILNMDWPEY-JRBXURKDSA-N|InChi: InChI=1S/C25H32F3N3O4/c1-17(30-8-12-34-21-5-2-3-6-22(21)35-16-25(26,27)28)13-18-14-19-7-10-31(9-4-11-32)23(19)20(15-18)24(29)33/h2-3,5-6,14-15,17,30,32H,4,7-13,16H2,1H3,(H2,29,33)/t17-/m1/s1/i8D2,12D2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24324376 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.|Products are for research use only. Not for human use.|