CD73 Mouse Monoclonal Antibody [A6F9]

Function :
5′-nucleotidase (5′-NT), also known as ecto-5′-nucleotidase or CD73 (cluster of differentiation 73), is an enzyme that in humans is encoded by the NT5E gene. CD73 commonly serves to convert AMP to adenosine. Ecto-5-prime-nucleotidase catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzyme is used as a marker of lymphocyte differentiation. Consequently, a deficiency of NT5 occurs in a variety of immunodeficiency diseases. Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate. Rare allelic variants are associated with a syndrome of adult-onset calcification of joints and arteries (CALJA) affecting the iliac, femoral, and tibial arteries reducing circulation in the legs and the joints of the hands and feet causing pain.{{Vortioxetine} MedChemExpress|{Vortioxetine} GPCR/G Protein|{Vortioxetine} Technical Information|{Vortioxetine} Description|{Vortioxetine} supplier|{Vortioxetine} Epigenetics} NT5E can act as an immune inhibitory control molecule.{{Daidzein} web|{Daidzein} Cell Cycle/DNA Damage|{Daidzein} Biological Activity|{Daidzein} Data Sheet|{Daidzein} custom synthesis|{Daidzein} Autophagy} Free adenosine generated by NT5E inhibits cellular immune responses and thereby promotes immune escape of tumor cells.